Minion can't be targeted and is destroyed by a spell

When a minion says it can't be targeted by spells, it means that your opponent cannot cast spells that specifically choose a minion and effect it negatively.  Spells can still affect these minions if they are not targeted.  Some spells like Chromatic Cold or Sunbloom target the battlefield directly, and other spells like Tempest and Plasma Storm don't target at all!  These spells intentionally still affect minions that cannot be targeted.

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